Inhibitory effects of antifungal proteins on human immunodeficiency virus type 1 reverse transcriptase, protease and integrase.
Identifieur interne : 000494 ( Main/Exploration ); précédent : 000493; suivant : 000495Inhibitory effects of antifungal proteins on human immunodeficiency virus type 1 reverse transcriptase, protease and integrase.
Auteurs : T B Ng [République populaire de Chine] ; T K Au ; T L Lam ; X Y Ye ; D C C. WanSource :
- Life sciences [ 0024-3205 ] ; 2002.
Descripteurs français
- KwdFr :
- Agents antiVIH (isolement et purification), Agents antiVIH (pharmacologie), Antifongiques (isolement et purification), Antifongiques (pharmacologie), Données de séquences moléculaires (MeSH), Fabaceae (composition chimique), Graines (composition chimique), Intégrase du VIH (effets des médicaments et des substances chimiques), Protéase du VIH (effets des médicaments et des substances chimiques), Protéines végétales (isolement et purification), Protéines végétales (pharmacologie), Séquence d'acides aminés (MeSH), Test ELISA (MeSH), Transcriptase inverse du VIH (antagonistes et inhibiteurs), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (effets des médicaments et des substances chimiques).
- MESH :
- antagonistes et inhibiteurs : Transcriptase inverse du VIH.
- composition chimique : Fabaceae, Graines.
- effets des médicaments et des substances chimiques : Intégrase du VIH, Protéase du VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- isolement et purification : Agents antiVIH, Antifongiques, Protéines végétales.
- pharmacologie : Agents antiVIH, Antifongiques, Protéines végétales.
- Données de séquences moléculaires, Séquence d'acides aminés, Test ELISA.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Anti-HIV Agents (isolation & purification), Anti-HIV Agents (pharmacology), Antifungal Agents (isolation & purification), Antifungal Agents (pharmacology), Enzyme-Linked Immunosorbent Assay (MeSH), Fabaceae (chemistry), HIV Integrase (drug effects), HIV Protease (drug effects), HIV Reverse Transcriptase (antagonists & inhibitors), HIV-1 (drug effects), Molecular Sequence Data (MeSH), Plant Proteins (isolation & purification), Plant Proteins (pharmacology), Seeds (chemistry).
- MESH :
- chemical , antagonists & inhibitors : HIV Reverse Transcriptase.
- chemical , drug effects : HIV Integrase, HIV Protease.
- chemical , isolation & purification : Anti-HIV Agents, Antifungal Agents, Plant Proteins.
- chemical , pharmacology : Anti-HIV Agents, Antifungal Agents, Plant Proteins.
- chemistry : Fabaceae, Seeds.
- drug effects : HIV-1.
- Amino Acid Sequence, Enzyme-Linked Immunosorbent Assay, Molecular Sequence Data.
Abstract
A variety of antifungal proteins were isolated from seeds of leguminous plants including French bean, cowpea, field bean, mung bean, peanut and red kidney bean. They were assayed for ability to inhibit human immunodeficiency virus type I (HIV-1) reverse transcriptase, protease and integrase, enzymes essential to the life cycle of HIV-1 . It was found that the cowpea beta-antifungal protein had a high potency in inhibiting HIV-1 protease and HIV-1 integrase. Cowpea alpha-antifungal protein was potent in inhibiting HIV-1 reverse transcriptase and HIV-1 integrase. Peanut antifungal protein was characterized by a high inhibitory activity against HIV-1 integrase and an intermediate potency in inhibiting HIV- I reverse transcriptase and HIV- I protease. French bean thaumatin-like protein expressed low HIV- I protease inhibitory activity and red kidney bean lectin inhibited HIV- I integrase by only a very small extent. Antifungal proteins from the field bean and mung bean had an intermediate potency in inhibitory HIV-1 protease and integrase. However, mung bean antifungal protein was not capable of inhibiting HIV-1 reverse transcriptase. The results indicate that nearly all leguminous antifungal proteins examined were able to inhibit HIV-1 reverse transcriptase, protease and integrase to some extent.
DOI: 10.1016/s0024-3205(01)01458-8
PubMed: 11855377
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Wan</name></author></analytic><series><title level="j">Life sciences</title><idno type="ISSN">0024-3205</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term><term>Anti-HIV Agents (isolation & purification)</term><term>Anti-HIV Agents (pharmacology)</term><term>Antifungal Agents (isolation & purification)</term><term>Antifungal Agents (pharmacology)</term><term>Enzyme-Linked Immunosorbent Assay (MeSH)</term><term>Fabaceae (chemistry)</term><term>HIV Integrase (drug effects)</term><term>HIV Protease (drug effects)</term><term>HIV Reverse Transcriptase (antagonists & inhibitors)</term><term>HIV-1 (drug effects)</term><term>Molecular Sequence Data (MeSH)</term><term>Plant Proteins (isolation & purification)</term><term>Plant Proteins (pharmacology)</term><term>Seeds (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents antiVIH (isolement et purification)</term><term>Agents antiVIH (pharmacologie)</term><term>Antifongiques (isolement et purification)</term><term>Antifongiques (pharmacologie)</term><term>Données de séquences moléculaires (MeSH)</term><term>Fabaceae (composition chimique)</term><term>Graines (composition chimique)</term><term>Intégrase du VIH (effets des médicaments et des substances chimiques)</term><term>Protéase du VIH (effets des médicaments et des substances chimiques)</term><term>Protéines végétales (isolement et purification)</term><term>Protéines végétales (pharmacologie)</term><term>Séquence d'acides aminés (MeSH)</term><term>Test ELISA (MeSH)</term><term>Transcriptase inverse du VIH (antagonistes et inhibiteurs)</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (effets des médicaments et des substances chimiques)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>HIV Reverse Transcriptase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>HIV Integrase</term><term>HIV Protease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Anti-HIV Agents</term><term>Antifungal Agents</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term><term>Antifungal Agents</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Transcriptase inverse du VIH</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fabaceae</term><term>Seeds</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Fabaceae</term><term>Graines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Intégrase du VIH</term><term>Protéase du VIH</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Agents antiVIH</term><term>Antifongiques</term><term>Protéines végétales</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents antiVIH</term><term>Antifongiques</term><term>Protéines végétales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Données de séquences moléculaires</term><term>Séquence d'acides aminés</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A variety of antifungal proteins were isolated from seeds of leguminous plants including French bean, cowpea, field bean, mung bean, peanut and red kidney bean. They were assayed for ability to inhibit human immunodeficiency virus type I (HIV-1) reverse transcriptase, protease and integrase, enzymes essential to the life cycle of HIV-1 . It was found that the cowpea beta-antifungal protein had a high potency in inhibiting HIV-1 protease and HIV-1 integrase. Cowpea alpha-antifungal protein was potent in inhibiting HIV-1 reverse transcriptase and HIV-1 integrase. Peanut antifungal protein was characterized by a high inhibitory activity against HIV-1 integrase and an intermediate potency in inhibiting HIV- I reverse transcriptase and HIV- I protease. French bean thaumatin-like protein expressed low HIV- I protease inhibitory activity and red kidney bean lectin inhibited HIV- I integrase by only a very small extent. Antifungal proteins from the field bean and mung bean had an intermediate potency in inhibitory HIV-1 protease and integrase. However, mung bean antifungal protein was not capable of inhibiting HIV-1 reverse transcriptase. The results indicate that nearly all leguminous antifungal proteins examined were able to inhibit HIV-1 reverse transcriptase, protease and integrase to some extent.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11855377</PMID><DateCompleted><Year>2002</Year><Month>03</Month><Day>07</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0024-3205</ISSN><JournalIssue CitedMedium="Print"><Volume>70</Volume><Issue>8</Issue><PubDate><Year>2002</Year><Month>Jan</Month><Day>11</Day></PubDate></JournalIssue><Title>Life sciences</Title><ISOAbbreviation>Life Sci</ISOAbbreviation></Journal><ArticleTitle>Inhibitory effects of antifungal proteins on human immunodeficiency virus type 1 reverse transcriptase, protease and integrase.</ArticleTitle><Pagination><MedlinePgn>927-35</MedlinePgn></Pagination><Abstract><AbstractText>A variety of antifungal proteins were isolated from seeds of leguminous plants including French bean, cowpea, field bean, mung bean, peanut and red kidney bean. They were assayed for ability to inhibit human immunodeficiency virus type I (HIV-1) reverse transcriptase, protease and integrase, enzymes essential to the life cycle of HIV-1 . It was found that the cowpea beta-antifungal protein had a high potency in inhibiting HIV-1 protease and HIV-1 integrase. Cowpea alpha-antifungal protein was potent in inhibiting HIV-1 reverse transcriptase and HIV-1 integrase. Peanut antifungal protein was characterized by a high inhibitory activity against HIV-1 integrase and an intermediate potency in inhibiting HIV- I reverse transcriptase and HIV- I protease. French bean thaumatin-like protein expressed low HIV- I protease inhibitory activity and red kidney bean lectin inhibited HIV- I integrase by only a very small extent. Antifungal proteins from the field bean and mung bean had an intermediate potency in inhibitory HIV-1 protease and integrase. However, mung bean antifungal protein was not capable of inhibiting HIV-1 reverse transcriptase. The results indicate that nearly all leguminous antifungal proteins examined were able to inhibit HIV-1 reverse transcriptase, protease and integrase to some extent.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>T B</ForeName><Initials>TB</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, China. biochemistry@cuhk.edu.hk</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Au</LastName><ForeName>T K</ForeName><Initials>TK</Initials></Author><Author ValidYN="Y"><LastName>Lam</LastName><ForeName>T L</ForeName><Initials>TL</Initials></Author><Author ValidYN="Y"><LastName>Ye</LastName><ForeName>X Y</ForeName><Initials>XY</Initials></Author><Author ValidYN="Y"><LastName>Wan</LastName><ForeName>D C C</ForeName><Initials>DC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Life Sci</MedlineTA><NlmUniqueID>0375521</NlmUniqueID><ISSNLinking>0024-3205</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.7.-</RegistryNumber><NameOfSubstance UI="D019427">HIV Integrase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.7.49</RegistryNumber><NameOfSubstance UI="D054303">HIV Reverse Transcriptase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 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MajorTopicYN="N">Plant Proteins</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012639" MajorTopicYN="N">Seeds</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>2</Month><Day>22</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>3</Month><Day>8</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>2</Month><Day>22</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11855377</ArticleId><ArticleId 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Wan</name><name sortKey="Ye, X Y" sort="Ye, X Y" uniqKey="Ye X" first="X Y" last="Ye">X Y Ye</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Ng, T B" sort="Ng, T B" uniqKey="Ng T" first="T B" last="Ng">T B Ng</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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